Visit Kind's page. About. Furthermore, as we consider technology development a core business of the group, we are continuously exploring ways to obtain richer single-cell datasets. Modifications of the conceptus exposed key genes regulating these tissues co-development. Jobs; Jobs Tips; 11 Recession-Proof Jobs; How to Get a Job; The Perfect Resume Looks Like This; How to Write A Cover Letter; 9 Attention-Grabbing Cover Letter Examples; New On Glassdoor; Best Cities for Jobs 2020; Company Reviews . A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Hubrecht Institute, NL. We are employing scDam&T to obtain a better understanding of the epigenetic mechanisms underlying lineage decisions in early embryogenesis, to identify the epigenetic trajectories of single cells that acquire malignant identities in tumorigenesis and to obtain insight into the role of chromatin in DNA double-strand repair. Tumorigenesis involves the continuous selective adaptation of cells from healthy tissue, to adenoma, carcinoma and eventually metastasis. 23. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ * Correspondence: j.kind@hubrecht.eu † These authors contributed equally to this work. Bob Roberts 2020-04-16 23:48:49? The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. Jop Kind, group leader at the Hubrecht Institute, has been awarded a NWO Vidi-grant. Jobs. Other Annotations. Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. Erasmus University Medical Center/ UFO Biosciences, NL . Jop Kind Group Jop Kind Oncode Investigator at Hubrecht Institute My Research. 2 day event 19 - 20 Apr. Articles … “Our overarching goal is to further research current pathways and discover new ones in order to better understand how cells repair this type of DNA damage”, says Knipscheer. Jop, now Group Leader at … Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research . Royal Netherlands Academy of Arts & Sciences (KNAW), Hubrecht Institute; 2015 2020. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (Figure 3). Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. As a postdoctoral fellow in the lab of Bas van Steensel at the NKI, Jop developed novel techniques to visualize and profile single-cell spatial genome organization. Since October 2014 he is Junior Group Leader at the Hubrecht Institute. Miao-Ping Chien. “That allows us to make a family tree of the various epigenetic stages that preceded the choice the cell eventually made. Cell division & chromosome segregation; Hubrecht Institute. Projects 1. Hubrecht Institute opens new laboratory building. Sara is now working as a computational biologist in the lab of Jop Kind at the Hubrecht Institute (Netherlands). Jop Kind. Read more | 11 November . Wouter de Laat Group. Technology development Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to … Since October 2014 he is Junior Group Leader at the Hubrecht Institute. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. PMID: 31118510 PMCID: PMC6546605 hubrecht.eu. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Hubrecht Institute. The European Research Council (ERC) awards grants to individual scientists of all nationalities and ages who perform groundbreaking research. The grant was awarded to only 327 out of 2506 applicants. We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (. Verified email at imba.oeaw.ac.at - Homepage. Reads . j.kind@hubrecht.eu. Hubrecht Institute. Hubrecht Institute launches new website! ERC-starting grant for Marvin Tanenbaum and Jop Kind. An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. Follow. … Jop Kind Group. Save the date! 13:05. Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Afterwards, Alexander van Oudenaarden, Mauro Muraro and Waleed Kholosy will also give talks and elaborate on some specific applications and usage of single cell technology. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. By Jop Kind, Hubrecht Institute. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. Sort by citations Sort by year Sort by title. Research output per year. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. Publications. ERC-starting grant for Marvin Tanenbaum and Jop Kind Marvin Tanenbaum and Jop Kind, both group leader at the Hubrecht Institute, are awarded an ERC-starting grant. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, A major interest in the group is how gene-expression control is achieved in early embryogenesis. 3 day event 20 - 22 Jan. Masterclass: Artificial intelligence and deep learning in basic research and clinical practice in Oncology: In-depth sessions. Oncode, starting from a deeper understanding of the basics of cancer, works to come up with better treatments and improved diagnostics. Publications. We have developed scDam&T, a method to simultaneously capture protein-DNA interactions and transcriptomes in the same cell (Rooijers et al, 2019, Nature Biotechnology) (Figure 1). Wednesday 22 July. torres-padilla@helmholtz-muenchen.de. ‪Hubrecht Institute‬ - ‪Cited by 3,964‬ - ‪Single cell epigenomics‬ Citations per year. Silke J. Read more | 5 November . Molecular mechanisms and regulation of DNA repair; Hubrecht Institute. About. Jop Kind. Hubrecht Institute, Developmental Biology and Stem Cell Research | 6,134 followers on LinkedIn. 3584 CT Utrecht Spatiotemporal regulation of genomic function; Hubrecht Institute. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. 13:05. Spatiotemporal regulation of genomic function; Hubrecht Institute. Additionally, they will investigate whether there are other, currently unknown pathways involved in repairing ICLs. Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Jop Kind Group Leader at Hubrecht Institute, Developmental Biology and Stem Cell Research Amsterdam en omgeving, Nederland Meer dan 500 connecties Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. This "Cited by" count includes citations to the following articles in Scholar. Verified email at hubrecht.eu. Partnership Agreement for Pontiac School District - Free download as PDF File (.pdf) or read online for free. Bob Roberts 2020-06-07 16:21:36 ? In this conversation. Contact. He will zoom in on single-cell epigenomics and multi-omics. Jop Kind lab. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. We are interested in how cells acquire new identities and traits in lineage specification events in mice and in cancer. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on … Tumor-cell trajectories in organoid and mouse models The group focuses on a specific type of DNA damage called a DNA interstrand crosslink (ICL). Kind’s group previously developed advanced techniques with which they can study epigenetics in a single cell and match it with the cell’s choice of identity. Verified account Protected Tweets @; Suggested users To achieve this, we make use of organoid and mouse models that capture tumorigenesis all the way from the initiating stages towards metastasis. The aim of the lab is to understand the principles governing cellular decision-making. Kind’s work has paved the way for the development of powerful technologies to map chromatin, or balled-up DNA, in single cells, earning him this year’s John Kendrew Award. Self-organization in embryology. Articles Cited by. Currently, there are more than 70 PhD students at the Hubrecht Institute. That knowledge underlines the link between alcohol consumption and cancer. Save the date for our Annual Conference! Jop Kind, Junior Group Leader at the Hubrecht Institute. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. Jop Kind. Cited by. 2 day event 19 - 20 Apr. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. Genome instability; UMC Utrecht. 3 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. martin 1st April 2015 News Read more Hiding in plain sight Job Corps is the largest Free residential education and job training program for young adults ages 16–24.. We connect you with the skills and education you need to get the career you want! Jop, now Group Leader at … 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. KIT, Royal Tropical Institute. 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Online event. j.kind@hubrecht.eu. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. To be announced. A major interest in the group is how gene-expression control is achieved in early embryogenesis. The following articles are merged in Scholar. Miao-Ping Chien. j.kind@hubrecht.eu. Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis. Additionally, they study how new cell types arise in the early development of mouse embryos, in which epigenetics plays an important role. ). This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. The Consolidator Grant is specifically awarded to researchers who have formed their own research group relatively recently and aim to further strengthen it further. ); s.kefalopoulou@hubrecht.eu (S.K.) Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. Furthermore, they aim to develop new techniques with which they can simultaneously perform multiple measurements in a single cell. Read the new partnership agreement between Pontiac School District and the state including exhibits of data on the schools achievement gaps. 13:35. Online event. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on the imaginative questions that led him to the prize . This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. Jop Kind, Junior Group Leader at the Hubrecht Institute. About the Hubrecht Institute PHOTO: EMBL . Scientists from the groups of Puck Knipscheer (Hubrecht Institute) and Ketan J. Patel (MRC Laboratory of Molecular Biology) studied the second line of … Jop Kind, Junior Group Leader at the Hubrecht Institute. Jobs. Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. Oncode Investigator at Hubrecht Institute My Research Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Projects 1. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. (Jop) Kind: Active at: The Netherlands Cancer Institute: Hubrecht Institute for Developmental Biology and Stem Cell Research: Email address: If you have any questions or problems regarding login, please contact narcis@dans.knaw.nl. Fingerprint. 23. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (. https://lnkd.in/ekB-EJy #outsmartingcancer Hubrecht Institute, Developmental Biology and Stem Cell Research Knipscheer and Kind receive prestigious ERC Consolidator grant hubrecht.eu By Jop Kind, Hubrecht Institute. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. This is harmful because it prevents the DNA from replicating and thereby makes it impossible for cells to divide. Cell division & chromosome segregation; Hubrecht Institute. Year; Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. Electronic address: j.kind@hubrecht.eu. Wouter de Laat Group. Here For You During COVID-19 NEW! We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. Together with her group, Knipscheer studies the repair pathways that cells use to correct ICLs. Puck Knipscheer is group leader at the Hubrecht Institute and Oncode investigator. Protein–DNA interactions are essential for establishing cell type–specific chromatin architecture and gene expression. Puck Knipscheer Group. Oncode is an independent institute dedicated to understanding cancer and translating research into practice. Publications 23. 3,331. Publications 23. Jop Kind is group leader at the Hubrecht Institute and Oncode investigator. Merged citations. Uppsalalaan 8 Geert Kops Group. Duplicate citations. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute . The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues - the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (Epi) to eventually form the all body. Save the date for our Annual Conference! In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. Additionally, they are planning to build so-called molecular time machines: by giving cells a mark in the earliest stages of embryonic development, the researchers can – once the cell has made its choice – trace the epigenetic status of the cells during the earlier stages of development. Maria-Elena Torres-Padilla is group leader and director of the Institute of Epigenetics and Stem Cells (IES), Helmholtz Center Munich and professor of Stem cell biology at the Ludwig-Maximilians University. 13:05. Go to Website Navigation: Home; about narcis; login; Nederlands; contact. In particular, the group is interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in living cells. 2 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Jop is currently an associate professor at the Hubrecht Institute in Utrecht where his lab continues to develop new techniques to single-cell profile gene-regulation to obtain better insights into the mechanisms that govern cell fate choice in development and disease. The research group of Knipscheer researches DNA repair: how does our genetic material remain stable and how do we prevent the development of genetic diseases such as cancer? Contact. To be announced. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Jop Kind Group. About. To obtain detailed insight into this trajectory, it is essential to capture all the stages with single-cell accuracy. 12:35. In total the NWO has awarded 87 experienced researchers a Vidi grant worth 800,000 euros. Salaries, reviews, and more - all posted by employees working at Hubrecht Institute. Annual Scientific Meeting. That way, we hope to better understand the relationship between epigenetics and the emergence of new cell types”, says Kind. Title. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Their combined citations are counted only for the first article. Jop Kind, group leader at the Hubrecht Institute, has been awarded the John Kendrew award. Best Cities for Jobs 2020 NEW! hubrecht.eu. Award ceremony photo gallery. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowl … Reads . Hubrecht Institute Summary: ... but instead attached to the ceiling at anchor points," says Jop Kind, group leader at the Hubrecht Institute. Friends raise €290.800,- for Hubrecht Institute. Login as Dr. J. EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. An ICL occurs when the two strands of our DNA are connected unnaturally. Annual Scientific Meeting. Jop Kind is group leader at the Hubrecht Institute and Oncode Investigator. PhD. ). See what employees say about what it's like to work at Hubrecht Institute. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. Read more | 18 November . KIT, Royal Tropical Institute. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. Biography. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. j.kind@hubrecht.eu. Anna Kicheva IST Austria Verified email at ist.ac.at. Jop Kind lab. Tanenbaum: Single molecule observation and manipulation of gene expression dynamics … Network. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The Netherlands; s.lochs@hubrecht.eu (S.J.A.L. More information. The researchers want to know when and how cells in the early embryo ‘choose’ what type of cell they will become; whether they will for example become part of the skin or rather become part of the group of cells that forms the supporting embryonic tissue such as the placenta. The Kind group researches gene regulation – how genes are turned on or off – and the influence of the packing of DNA, the epigenetics, on this mechanism. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. Geert Kops Group. Uppsalalaan 8 Jop Kind The organization of DNA within the eukaryotic nucleus is important for cellular processes such as regulation of gene expression and repair of DNA damage. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. His group is focused on understanding how spatial and temporal changes in genome architecture affect gene expression. 12:35. Past events. Hubrecht Institute, NL. The grant enables them to develop their own innovative line of research and set up their own research group. Ester Frische; Mariëlle Harlé; Yuva Oz; Jacqueline Staring; Peter Thijssen; More information will follow. The John Kendrew Young Scientist Award (JKA) was launched in 2007 as an initiative from the EMBL Pensioner’s Association to honour EMBL’s first Director General, Sir John Kendrew (1975-1982), and to support scientists in the early stages of their career. jop kind Hubrecht Institute Verified email at hubrecht.eu. 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